儿童,青少年和成年人注意力缺陷多动性障碍的死亡率:全国性的队列研究
Søren Dalsgaard1, Søren Dinesen Østergaard2, James F Leckman3
1National Centre for Register-Based Research, Department of Economics and Business, School of Business and Social Sciences, Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus and Copenhagen, Denmark; Centre for Integrated Register-Based Research at Aarhus University (CIRRAU), Aarhus, Denmark; Department for Child and Adolescent Psychiatry, Hospital of Telemark, Kragerø, Norway.
注意缺陷多动症 (ADHD) 与显著更高的死亡率有关,特别是在事故中. 被诊断为ADHD的成年人面临更大的风险,女性的死亡率高于男性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 注意缺陷多动性障碍 (ADHD) 是一种流行的神经发育障碍.
- ADHD与增加死亡风险的疾病有关,但ADHD对死亡率的独立影响尚不清楚.
研究的目的:
- 为了研究ADHD和死亡率之间的关联,在一个大规模的丹麦人口队列中.
主要方法:
- 利用丹麦国家登记册,从出生到2013年,跟踪192万个 (32,061个ADHD) 个体.
- 使用波桑回归来估计调整后的死亡率比率 (MRRs),控制各种人口和家庭因素.
主要成果:
- 与没有ADHD的人相比,患有ADHD的人的死亡率 (MRR=2.07) 高2.07倍.
- 事故是导致死亡的主要原因. 成年期被诊断患有多动症的个体的死亡风险最高 (MRR=4.25).
- 即使在排除并发症后,ADHD仍然与增加的死亡率有关,女性的发病率更高.
结论:
- ADHD与死亡率的增加显著相关,主要是由于事故等非自然原因.
- 成年人诊断的ADHD比儿童或青少年诊断的死亡风险更高.
- 在考虑到并发症后,ADHD的过度死亡率仍然存在,不成比例地影响女性.
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