在家庭中对子宫前的敏感性和HLA DR4之间的关联
D C Kilpatrick1, W A Liston, F Gibson
1Blood Transfusion Centre, Royal Infirmary, Edinburgh.
Lancet (London, England)
|November 4, 1989
概括
患有先兆子史的女性,如果他们的姐妹也患有这种疾病,患这种疾病的风险要高得多. 这种遗传联系可能涉及HLA DR4.
科学领域:
- 产科和妇科 产科和妇科
- 免疫遗传学 免疫遗传学
- 生殖医学 生殖医学
背景情况:
- 孕前是一个严重的妊娠并发症.
- 家庭病史,特别是姐妹病史,表明子前症的遗传成分.
- 人类白细胞抗原 (HLA) 基因已知在免疫反应和怀孕结果中起作用.
研究的目的:
- 为了调查患有受影响的姐妹的妇女中蛋白尿性妊娠前的家族风险.
- 探索人类白细胞抗原 (HLA) DR4与对子宫前的敏感性之间的关联.
- 检查胎儿与母亲的HLA共享在子宫前中的作用.
主要方法:
- 研究了一组56名女性,她们有蛋白尿性先兆子的病史,她们是Parous姐妹.
- 姐妹的子宫前发病率与分娩医院一般人口的比较.
- 在受影响和不受影响的姐妹中分析HLA DR4频率和HLA DR4与配偶的共享.
主要成果:
- 在受影响妇女的姐妹中,蛋白尿前明显更常见 (11%) 与普通人口相比 (2%),表明6.0的相对风险.
- 在怀孕引起的高血压 (44%) 的姐妹中,HLA DR4的发生频率高于怀孕正常的 (19%) 姐妹.
- 与正常血压的姐妹 (0%) 相比,怀孕引起的高血压的姐妹与他们的配偶 (29%) 共享HLA DR4的比例更高.
结论:
- 对子宫前的遗传敏感性与HLA DR4有关.
- 胎儿与母亲共享单个衰退的HLA相关基因可能会导致对子宫前的敏感性.
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