三种静脉注射双酸盐在与癌症相关的高血症中的比较
S H Ralston1, S J Gallacher, U Patel
1University Department of Medicine, Glasgow Royal Infirmary.
Lancet (London, England)
|November 18, 1989
概括
帕米德罗纳特,克洛德罗纳特和埃迪德罗纳特通过抑制骨再吸收来治疗与癌症相关的高血症. 帕米德罗纳酸显示出优越的功效,导致患者血清水平更快,更长时间的正常化.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 内分泌学 在内分泌学.
背景情况:
- 与癌症相关的高血是恶性瘤的常见并发症.
- 双酸盐是通过抑制骨再吸收来控制高血症的基石.
研究的目的:
- 为了比较三种静脉注射双酸盐在治疗与癌症相关的高血症中的疗效和功效.
- 为了评估血清正常化的开始,持续时间和程度,使用帕米德罗纳特,克洛德罗纳特和埃迪德罗纳特.
主要方法:
- 一项随机试验涉及48名患有癌症相关高血症的患者.
- 患者接受了帕米德罗纳酸 (30毫克一次性输注),克洛德罗纳酸 (600毫克一次性输注) 或埃迪德罗纳酸 (7.5毫克/公斤/天3天).
- 所有参与者都接受了治疗前用正常盐水补水.
主要成果:
- 所有的双酸盐都通过抑制骨再吸收来有效降低血清.
- 在测试的药物中,帕米德罗纳酸表现出最大的强度.
- 与克洛德罗纳特和埃迪德罗纳特相比,帕米德罗纳特组中更高比例的患者实现了正常血症,发病速度更快,效果持续时间更长.
结论:
- 帕米德罗纳酸是一种高度有效的双酸盐,用于控制与癌症相关的高血症.
- 与克洛德罗纳特和埃迪德罗纳特相比,帕米德罗纳特在作用速度,效果持续时间和达到正常血症方面具有优势.
- 静脉输入双酸盐治疗,特别是帕米德酸盐,对于控制癌症患者的高血症至关重要.
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