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Updated: Apr 16, 2026

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
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提亚酸天然产品的化学酶合成,其中包括一种酶催化形式的 [4 + 2] 循环添加

Walter J Wever1, Jonathan W Bogart1, Joshua A Baccile2

  • 1†Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

Journal of the American Chemical Society
|March 6, 2015
PubMed
概括

研究人员确定了TclM,这是催化硫抗生素生物合成的最后一步的酶. 这涉及脱氨酸之间独特的 [4+2] 循环添加反应,完成了 thiazolyl 路径.

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