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脑下垂体Agrp神经元驱动除了养之外的刻板印象行为

Marcelo O Dietrich¹, Marcelo R Zimmer², Jeremy Bober³

¹Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Graduate Program in Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90035, Brazil.

|March 10, 2015

概括

脑下垂体Agouti相关 (Agrp) 神经元,通常与食有关,也驱动食和重复性行为. 食物消费扭转了这些刻板印象的行为,揭示了Agrp神经元在行为调节中的更广泛作用.

科学领域:

神经科学是一个神经科学.
行为生物学行为生物学
内分泌学在内分泌学.

背景情况:

低垂体阿古蒂相关 (Agrp) 神经元因其在调节养行为中的关键作用而得到认可.
神经系统整合了感官和感官信息,以协调目标导向的行动.

研究的目的:

为了研究下丘脑Agrp神经元超越养的更广泛的行为功能.
探索Agrp神经元在成年小鼠编排复杂行为中的作用.

主要方法:

在没有食物的情况下,成年小鼠Agrp神经元的激活.
观察和量化触发行为 (食,重复行为).
评估焦虑程度和食物消费对行为的影响.
对NPY5受体信号通路的研究.

主要成果:

在没有食物的情况下激活Agrp神经元,诱导食和刻板印象的重复行为.
食物消费有效地扭转了这些由Agrp神经元引起的行为.
激活Agrp神经元与减少焦虑有关.
NPY5受体信号传递对于调解重复行为至关重要,但对养的影响最小.

结论:

脑下垂体Agrp神经元在控制重复行为方面发挥着重要作用,除了它们在养中的已知功能外.
神经类信号传递,特别是通过NPY5受体,与Agrp神经元介导的重复行为有关.
这些发现扩大了我们对能量稳态电路的理解,并为典型行为特征的疾病提供了潜在的治疗点.

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