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Updated: Apr 16, 2026

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity
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在瘤生长和转移的小鼠模型中的全基因组CRISPR屏幕

Sidi Chen1, Neville E Sanjana2, Kaijie Zheng3

  • 1David H. Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Cell
|March 10, 2015
PubMed
概括

这项研究使用CRISPR/Cas9基因选来识别驱动癌症生长和转移的基因. 发现特定基因的功能丧失突变加速了小鼠的瘤扩散.

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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