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DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers
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通过双螺旋体的分子间隙调节DNA纳米粒子超级网的动态调节

Suchetan Pal1,2, Yugang Zhang2, Sanat K Kumar1

  • 1†Department of Chemical Engineering, Columbia University, New York City, New York 10027, United States.

Journal of the American Chemical Society
|March 10, 2015
PubMed
概括

研究人员开发了一种新方法,使用DNA动态调整纳米粒子超级网间距. 这种基于DNA的纳米粒子组件允许可调节的光学特性和热稳定,可重新配置的材料.

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Nucleosome Remodeling02:54

Nucleosome Remodeling

Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
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DNA Topoisomerases

Topoisomerases are enzymes that relax overwound DNA molecules during various cell processes, including DNA replication and transcription. These enzymes regulate positive and negative DNA supercoiling without changing the nucleotide sequence. DNA overwinding in a clockwise direction results in positively supercoiled DNA, whereas underwinding in a counterclockwise direction produces negatively supercoiled DNA.
Types and Mechanism of action
Topoisomerases are divided into two main types.  Type I...
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Single-Strand DNA Binding Proteins

For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...