牛皮的临床改善,具有针对性地准了23-interleukin
Tamara Kopp1, Elisabeth Riedl2, Christine Bangert3
11] Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases, University of Vienna Medical School, 1090 Vienna, Austria [2] Juvenis Medical Center, 1010 Vienna, Austria.
Nature
|March 11, 2015
概括
针对牛皮的向治疗方法Tildrakizumab在I期研究中有效降低了疾病的严重程度. 这种联素-23p19抑制剂在中度至重度牛皮的患者中显示出显著的临床改善.
科学领域:
- 免疫皮肤学 免疫皮肤学
- 药理学 药理学是指药理学的学科.
背景情况:
- 牛皮是一种慢性免疫介导的皮肤疾病,影响身体和心理健康.
- 准介素-23通路显示出有效的牛皮治疗的希望.
研究的目的:
- 评估IL-23p19抑制剂Tildrakizumab在中度至重度牛皮的临床疗效.
- 为IL-23p19向治疗提供临床概念验证.
主要方法:
- 一期,随机,安慰剂控制,顺序,增高的多剂量研究.
- 提尔德拉基祖马布用于中度至重度牛皮的患者.
- 根据牛皮区域和严重性指数 (PASI) 评分来评估有效性.
主要成果:
- 在第1部分和第3部分的组合中,所有受试者在196天前以3和10毫克/千克的剂量达到PASI75.
- 在第二部分,分别有67% (3 mg/kg) 和93% (10 mg/kg) 的患者在第112天达到PASI75.
- 在PASI得分和组织学发现中观察到显著的改善.
结论:
- 蒂尔德拉基祖马布有效向IL-23p19,导致牛皮的临床改善显著.
- 特定的IL-23p19抑制是适度至重症牛皮的可行的治疗策略.
相关概念视频
01:24T Cell Types and Functions
3.5K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.5K
01:22iPS Cell Differentiation
3.3K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.3K