家族性高胆固醇血症与2型糖尿病患病率之间的关联
Joost Besseling1, John J P Kastelein1, Joep C Defesche2
1Department of Vascular Medicine, Academic Medical Centre, Amsterdam, the Netherlands.
JAMA
|March 11, 2015
概括
患有家族性高胆固醇血症的人患2型糖尿病的患病率较低. 这表明胆固醇运输和糖尿病发展之间存在潜在联系,需要进一步调查.
科学领域:
- 心血管遗传学 心血管遗传学
- 代谢障碍 代谢障碍 代谢障碍
- 分子生物学分子生物学
背景情况:
- 家庭性高胆固醇血症 (FH) 损害胆固醇吸收,而他类药物增加了它,增加了2型糖尿病 (T2DM) 的风险.
- 一个假设提出了跨膜胆固醇运输和T2DM发展之间的联系.
研究的目的:
- 调查T2DM流行率与FH之间的关联.
- 根据FH突变类型,探索T2DM患病率的变化.
主要方法:
- 在荷兰 (1994-2014) 接受FHDNA检测的63320名个体的横截面研究.
- 根据严重程度对FH突变的分类:LDL受体与APOB基因突变,以及受体阴性与受体缺乏的LDL受体突变.
主要成果:
- 在FH患者中,T2DM患病率较低 (1.75%),与未受影响的亲属相比 (2.93%) (OR,0.62).
- 在FH中调整后的T2DM患病率为1.44% (OR,0.49).
- 患病率因突变类型而异:APOB (1.91%) 与LDL受体 (1.33%),受体缺陷 (1.44%) 与受体阴性 (1.12%).
结论:
- 在FH患者中,T2DM的患病率明显低于未受影响的亲属.
- 根据突变类型观察到的变异性表明存在微妙的关系.
- 需要进一步的纵向研究来确认LDL受体介导的胆固醇运输与T2DM之间的潜在因果关系.
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