在基生物合成中分子内质子转移的可行性 - - 指导原则
Young J Hong1, Dean J Tantillo1
1Department of Chemistry, University of California Davis, One Shields Avenue, Davis, California 95616, United States.
Journal of the American Chemical Society
|March 13, 2015
概括
量子化学计算评估了基生物合成中的质子转移反应. 为这些复杂的生化途径提出了指导原则.
科学领域:
- 生物化学 生物化学
- 有机化学 有机化学
- 计算化学的计算化学
背景情况:
- 烯生物合成涉及复杂的反应机制.
- 假设分子内质子转移反应是关键步骤.
研究的目的:
- 评估拟议的基生物合成中的分子内质子转移反应的可行性.
- 为这些反应建立指导原则.
主要方法:
- 使用了量子化学计算.
- 根据理论结果评估反应的可行性.
主要成果:
- 确定了许多分子内质子转移反应的可行性.
- 确定了影响反应通路的关键因素.
结论:
- 为拟议的反应机制提供理论支持.
- 确立了指导未来生物合成研究的原则.
相关概念视频
Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration
10.2K
The rate of acid-catalyzed hydration of alkenes depends on the alkene's structure, as the presence of alkyl substituents at the double bond can significantly influence the rate.
10.2K
Carbon-dioxide Fixation
906
Carbon dioxide fixation in prokaryotes enables the assimilation of inorganic carbon into organic molecules, supporting biosynthetic pathways, sustaining ecosystems, and contributing to the global carbon cycle. It also has industrial applications in carbon capture and bioproduct synthesis. Autotrophic organisms rely on this process to utilize CO₂ as a carbon source in diverse environments.The Calvin CycleThe Calvin cycle is the most widespread carbon fixation mechanism, primarily used by...
906
The Calvin Benson Cycle
8.0K
Ribulose 1,5- bisphosphate carboxylase/oxygenase (RuBisCo) is a critical enzyme that catalyzes carbon dioxide assimilation during photosynthesis. However, it is an inefficient enzyme, having an extremely slow catalytic rate. A typical enzyme can process about a thousand molecules per second; however, RuBisCo fixes only around three-carbon dioxides per second. Photosynthetic cells compensate for this slow rate by synthesizing very high amounts of RuBisCo, making it the most abundant single...
8.0K
Photochemical Electrocyclic Reactions: Stereochemistry
2.5K
The absorption of UV–visible light by conjugated systems causes the promotion of an electron from the ground state to the excited state. Consequently, photochemical electrocyclic reactions proceed via the excited-state HOMO rather than the ground-state HOMO. Since the ground- and excited-state HOMOs have different symmetries, the stereochemical outcome of electrocyclic reactions depends on the mode of activation; i.e., thermal or photochemical.
Selection Rules: Photochemical Activation
Selection Rules: Photochemical Activation
2.5K
Thermal and Photochemical Electrocyclic Reactions: Overview
3.3K
Electrocyclic reactions are reversible reactions. They involve an intramolecular cyclization or ring-opening of a conjugated polyene. Shown below are two examples of electrocyclic reactions. In the first reaction, the formation of the cyclic product is favored. In contrast, in the second reaction, ring-opening is favored due to the high ring strain associated with cyclobutene formation.
3.3K
Amino Acid Biosynthetic Pathways
1.7K
Amino acid biosynthesis is essential for cell growth, protein synthesis, and metabolic regulation. Cells generate essential and non-essential amino acids from metabolic intermediates to sustain vital biological functions. These intermediates originate from key metabolic pathways: glycolysis, the tricarboxylic acid (TCA) cycle, and the pentose phosphate pathway. Important precursors include α-ketoglutarate, pyruvate, oxaloacetate, phosphoenolpyruvate, and erythrose-4-phosphate, which...
1.7K


