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通过TREK-2的结构和与Prozac的复合体揭示了K2P通道封锁机制

Yin Yao Dong1, Ashley C W Pike1, Alexandra Mackenzie2

  • 1Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.

Science (New York, N.Y.)
|March 14, 2015
PubMed
概括

晶体结构揭示了TREK-2通道如何改变形状以应对拉伸和脂肪酸等刺激. 这解释了道封锁和潜在的Prozac非目标效应.

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