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Updated: Apr 15, 2026

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
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MAD2L2通过抑制5'末端切除来控制端粒和DNA断裂的DNA修复

Vera Boersma1, Nathalie Moatti1, Sandra Segura-Bayona1

  • 1Division of Molecular Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

Nature
|March 25, 2015
PubMed
概括

MAD2L2是一种新型的DNA修复因子,通过抑制5'末端切除,促进端粒融合和基因组不稳定. 它的耗尽使端粒稳定,并通过NHEJ防止DNA双链断裂修复.

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