两个胰岛素受体决定了植物的替代性翅膀形态
Hai-Jun Xu1, Jian Xue1, Bo Lu1
1State Key Laboratory of Rice Biology and Ministry of Agriculture Key Laboratory of Agricultural Entomology, Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China.
植物的两个胰岛素受体控制着翅膀的发育. InR1促进了长翅膀,而InR2抑制了它,揭示了翅膀多性和表型可塑性的分子基础.
科学领域:
- 昆虫学 昆虫学是一门学科.
- 发展生物学 发展生物学
- 进化生物学 进化生物学
背景情况:
- 翅膀多功能,昆虫的一个特征,涉及到长翅膀 (能够飞行) 和短翅膀 (无飞行) 的替代形式.
- 环境线索影响了翅膀形态的发展,可能由荷尔蒙介导,但分子机制尚不清楚.
研究的目的:
- 为了阐明控制迁徙的棕色植物,Nilaparvata lugens.控制翅膀形态决定的分子机制.
- 确定关键的分子参与者,调节长翼和短翼之间的发育转换.
主要方法:
- 研究了两个胰岛素受体 (InR1和InR2) 在Nilaparvata lugens翅膀发育中的作用.
- 分析了酸丁醇-3-OH激酶 (PI(3) K) -蛋白激酶B (Akt) 信号通路和Foxo转录因子的参与.
- 检查了连接物Ilp3对翅膀形态决定的影响.
主要成果:
- InR1和InR2通过调节FOXO活动在翅膀形态的决定中发挥了相反的作用.
- InR1的激活促进了长翅膀,而它的不激活导致了短翅膀.
- InR2 负面调节 InR1-PI(3) K-Akt 路径;其抑制导致长翅膀.
- 接体Ilp3触发长翅形态的发展.
结论:
- 确定了昆虫中翅膀多功能调节的分子基础,涉及对抗胰岛素受体的作用.
- 证明了替代发育结果的二元控制机制,增强了对表型可塑性的理解.
- 提供了对控制昆虫翅膀形态决定的发育途径的新见解.
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