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产品的形成由Promiscuous Lanthipeptide 合成酶 ProcM 在动力控制下进行

Yi Yu1, Subha Mukherjee1, Wilfred A van der Donk1

  • 1†Department of Biochemistry, ‡Department of Chemistry, and §Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, 600 S. Mathews Ave. Urbana, Illinois 61801, United States.

Journal of the American Chemical Society
|March 25, 2015
PubMed
概括

兰氏合成酶ProcM表现出高产品选择性,突变影响循环化速率和区域选择性. 最初的环形形成决定了最终产品的拓,而不是热力学控制.

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