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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
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针对急性鼻炎的全身皮质类固醇治疗.

Roderick P Venekamp1, Matthew J Thompson2, Maroeska M Rovers3

  • 1Division Surgical Specialties, Department of Otorhinolaryngology, University Medical Center Utrecht, the Netherlands2Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands.

JAMA
|March 25, 2015
PubMed
概括
此摘要是机器生成的。

对于严重的急性鼻炎,与抗生素相结合的口服皮质类固醇可能比单独服用抗生素可以提供短期的症状缓解. 然而,单独服用口服皮质类固醇并不能改善急性鼻炎的结果.

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科学领域:

  • 耳鼻喉科 耳鼻喉科 耳鼻喉科
  • 药理学 药理学是指药理学的学科.
  • 临床医学 临床医学

背景情况:

  • 急性鼻炎是一种常见的疾病,通常通过各种治疗方法进行管理.
  • 皮质类固醇在治疗急性鼻炎中的作用仍然是临床调查的主题.

研究的目的:

  • 评估口服或腹腔内皮质类固醇与安慰剂或NSAID治疗急性鼻炎的疗效.
  • 为了确定皮质类固醇是否改善急性鼻炎患者的临床结果.

主要方法:

  • 随机对照试验的系统审查和元分析.
  • 皮质类固醇干预与安慰剂或非类固醇抗炎药物 (NSAIDs) 的比较.

主要成果:

  • 口服皮质类固醇与抗生素相结合,在严重急性鼻炎的短期症状缓解方面显示出适度的益处.
  • 与对照组相比,用皮质类固醇单独治疗并没有显示出改善的临床结果.

结论:

  • 组合疗法 (口服皮质类固醇加抗生素) 可能对严重的急性鼻炎症状管理有益.
  • 对于临床诊断的急性鼻炎,不建议使用皮质类固醇作为单一疗法.