通过饮食促进健康和寿命:从模型生物到人类
Luigi Fontana1, Linda Partridge2
1Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Clinical and Experimental Science, Brescia University, 25123 Brescia, Italy; CEINGE Biotecnologie Avanzate, 80145 Napoli, Italy.
Cell
|March 28, 2015
概括
饮食变化,包括饮食时间和营养摄入量,可以改善衰老和健康. 了解这些机制可能会导致新的干预措施,以实现更健康的衰老.
科学领域:
- 老年学和营养科学研究
- 研究饮食对衰老和与年龄有关的疾病的生物学影响.
背景情况:
- 减少食物摄入量和特定营养素的修改表明,有望改善各种物种的衰老和相关疾病.
- 饮食时间,如间歇性禁食和日间食模式,可以改善健康和功能,而不会改变总体热量摄入量.
研究的目的:
- 探索衰老和与年龄有关的疾病的饮食干预的基础机制.
- 确定促进健康的关键营养素和饮食模式.
- 调查微生物群在饮食中介衰老影响中的作用.
主要方法:
- 在老龄化模型中,对饮食限制,食时间和特定营养素摄入量的最新发现的审查.
- 分析饮食影响的代谢,分子和细胞途径.
- 检查影响饮食反应的遗传变异.
主要成果:
- 饮食时间和特定营养素的减少 (例如蛋白质,氨基酸) 对于健康的持续时间至关重要,独立于整体的卡路里减少.
- 饮食调节对微生物群产生影响,具有潜在的长期和代际影响.
- 连接饮食与改善衰老的机制正在被阐明,突出代谢和细胞适应.
结论:
- 饮食干预,专注于食时间和营养成分,提供了一种有效的策略来对抗衰老和疾病.
- 了解潜在的机制有助于制定有针对性的饮食和药理策略.
- 这些方法旨在利用饮食限制的好处,克服自愿遵守的挑战.
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