通过基于DNA的三通交叉路口进行收费运输.
Ryan M Young1,2, Arunoday P N Singh1, Arun K Thazhathveetil1
1†Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, United States.
Journal of the American Chemical Society
|March 31, 2015
概括
研究人员研究了DNA三向结 (3WJs) 中的电荷传输动态. 他们发现,形状波动的门孔运输,影响电子合沿着DNA序列.
科学领域:
- 分子生物学分子生物学
- 生物物理学的生物物理.
- 材料科学 材料科学 材料科学
背景情况:
- 基于DNA的分子电子需要在复杂的架构中高效的电荷传输.
- 在线性DNA中已经证明了电荷传输,但其在三向结 (3WJs) 等分支结构中的行为仍然不清楚.
研究的目的:
- 为了研究穿过DNA三向结的孔运输和捕获的动态和效率.
- 阐明3D DNA架构中控制电荷传输的机制.
主要方法:
- 五秒短暂吸收光谱检测电荷载体动态.
- 模拟分子动力学模拟以建模DNA构造变化和电子合.
主要成果:
- 通过DNA3WJ观察和特征穿过孔运输.
- 在DNA基本状态的 conformational 波动被确定为一个关键的关键因素封锁电荷传输.
结论:
- 在DNA3WJ中,电荷传输是由动态形状变化调节的.
- 这些发现为分子电子学的复杂DNA结构中电荷传输的基本原理提供了洞察力.
更多相关视频
07:50Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
Published on: November 25, 2015
15.1K
11:27Single-Molecule Förster Resonance Energy Transfer Methods for Real-Time Investigation of the Holliday Junction Resolution by GEN1
Published on: September 18, 2019
10.1K
相关概念视频
Contact-dependent Signaling
48.9K
Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
Gap Junctions
In animal cells, gap junctions are formed...
48.9K
P-N junction
1.8K
A p-n junction is formed when p-type and n-type semiconductor materials are joined together. At the interface of the p-n junction, holes from the p-side and electrons from the n-side begin to diffuse into the opposite sides due to the concentration gradient. This diffusion of carriers leads to a region around the junction where there are no free charge carriers, known as the depletion region. The charge density within the depletion region for the n-side and p-side can be described by the...
1.8K
Gene Conversion
10.9K
Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
10.9K
Single-Strand DNA Binding Proteins
17.3K
For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
17.3K
DNA-only Transposons
18.9K
DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
The donor site from where the transposon is excised is either degraded or...
The donor site from where the transposon is excised is either degraded or...
18.9K
Homologous Recombination
65.9K
The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
65.9K
