在先天性心脏病中出现冠状管间
C M Bloor1, J F Keefe, M J Browne
1Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA.
Circulation
|April 1, 2015
概括
在先天性心脏病中,冠状管间瘤的规模与对照组没有差异,但在经过手术的患者中,随着年龄的增长而增加. 手术创伤不太可能是增加瘤的原因.
科学领域:
- 心血管研究研究心血管研究
- 儿童心脏病学 儿童心脏病学
- 解剖学研究 解剖学研究
背景情况:
- 冠状动脉间瘤对于心肌血液供应至关重要.
- 它们在先天性心脏病 (CHD) 中的作用尚未完全理解.
- 正常的解瘤直径可达74微米.
研究的目的:
- 研究心血管疾病患者冠状动脉间瘤的频率和大小.
- 为了比较心血管疾病患者和对照对象的瘤.
- 探索影响解的因素,如年龄,色和手术干预.
主要方法:
- 从心脏病患者的35颗心脏进行了组织学检查.
- 对冠状动脉间瘤的大小和频率的比较分析.
- 与临床数据相关的发现的统计评估 (年龄,色,外科病史).
主要成果:
- 不经手术的心脏病心脏的瘤与对照患者相似,不论是贫血,高或色.
- 蓝色的患者比蓝色的患者年轻得多.
- 经过手术的患者表现出明显增加的瘤的频率和大小.
- 在经过手术的患者中,无论手术后的存活时间 (≤48小时 vs. >5周) 是否有所增加,都观察到解.
- 在5岁以上的心脏病患者中,观察到动脉瘤的频率和大小显著增加.
结论:
- 在心血管疾病中,冠状动脉间瘤与未经手术的对照病例没有显著差异.
- 年龄是一个重要的因素,在老年慢性心脏病患者 (>5年) 中,解瘤的规模和频率增加.
- 手术干预可能会影响解,但这种影响不仅仅归因于手术创伤.
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