收养细胞转移作为人类癌症个性化免疫疗法
Steven A Rosenberg1, Nicholas P Restifo1
1Surgery Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 9000 Rockville Pike, CRC Building, Room 3W-3940, Bethesda, MD 20892, USA. sar@nih.gov restifo@nih.gov.
概括
采用细胞疗法 (ACT) 提供使用免疫细胞的个性化癌症治疗. 工程免疫细胞增强了ACT.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 生物技术是生物技术.
背景情况:
- 采用细胞疗法 (ACT) 利用免疫细胞进行癌症治疗.
- 自然发生的瘤反应性淋巴细胞在黑色素瘤中表现出成功.
- 向癌症特异性突变是一个关键机制.
研究的目的:
- 审查采用细胞治疗在癌症治疗中的进展和应用.
- 突出ACT在治疗各种癌症的潜力,包括上皮癌.
- 讨论基因工程在提高ACT疗效方面的作用.
主要方法:
- 审查关于采用细胞治疗的现有文献.
- 用ACT治疗的患者临床结果的分析.
- 检查用于淋巴细胞修饰的基因工程技术.
主要成果:
- 在接受自然发生瘤反应性淋巴细胞治疗的黑色素瘤患者中观察到持久,完全的回归.
- 将ACT应用扩展到常见的上皮癌.
- 在癌症治疗中成功使用转基因淋巴细胞 (表达T细胞受体或仿真抗原受体).
结论:
- 收养细胞疗法是一种有前途的个性化癌症治疗方法.
- 基因工程显著扩大了ACT的范围和成功.
- ACT有可能用于治疗更广泛的癌症.
相关概念视频
Tumor Immunotherapy
2.5K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.5K
Combination Therapies and Personalized Medicine
6.4K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.4K
Cancer Vaccines
1.4K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.4K
Targeted Cancer Therapies
9.2K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.2K
Targeted Cancer Therapies
1.8K
1.8K
Cancer
56.3K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
56.3K


