通过大致中和抗体3BNC117在感染HIV-1的人类中抑制病毒性血
Marina Caskey1, Florian Klein1, Julio C C Lorenzi1
1Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10065, USA.
Nature
|April 10, 2015
概括
一种新的人类抗体,3BNC117显示出治疗HIV-1的前景. 这种强大的抗体在1期临床试验中安全地降低了病毒载量,这表明HIV-1预防和治愈的潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 临床医学 临床医学
背景情况:
- 使用单克隆抗体的第一代HIV-1免疫疗法无效.
- 抗体发现的进步已经确定了针对HIV-1的强大,广泛中和的抗体.
- 这些新抗体在人类中的治疗潜力仍然未被评估.
研究的目的:
- 评估人类新型CD4结合位抗体3BNC117的安全性和有效性,在首次在人体临床试验中进行.
- 评估3BNC117在HIV-1感染个体中使用后的药理动力学和病毒载量减少.
主要方法:
- 一个剂量升级的第一阶段临床试验在未感染和HIV-1感染的个体中进行.
- 参与者接受了人类单克隆抗体3BNC117.7的输注.
- 对病毒载量,抗体耐受性和药理动力学进行了监测.
主要成果:
- 3BNC117输液耐受性良好,药理动力学良好.
- 一次30毫克/公斤的3BNC117输注可将HIV-1病毒载量降低0.8-2.5 log10.
- 病毒载量减少持续了28天,耐药菌株的出现变化.
结论:
- 3BNC117作为减少HIV-1病毒性血症的单一药物是安全有效的.
- 使用广泛中和抗体的免疫疗法代表了预防,治疗和治愈HIV-1的潜在新策略.
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