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Updated: Apr 15, 2026

Xenopus laevis as a Model to Identify Translation Impairment
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应对压力的反应. 翻译启动因子中的突变确定了增强记忆的化合物的标

Yusuke Sekine1, Alisa Zyryanova2, Ana Crespillo-Casado2

  • 1University of Cambridge, Cambridge Institute for Medical Research (CIMR), the Wellcome Trust MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0XY, UK. dr360@medschl.cam.ac.uk ys412@cam.ac.uk.

Science (New York, N.Y.)
|April 11, 2015
PubMed
概括

一项新的研究显示,综合应激反应抑制剂ISRIB针对eIF2B三角形子单元. 这一发现澄清了ISRIB如何调节展开的蛋白质反应并增强认知功能.

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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