癌症治疗中的免疫检查点向:与治愈潜力结合的策略
Padmanee Sharma1, James P Allison2
1Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Genitourinary Medical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA.
Cell
|April 11, 2015
概括
向癌症治疗和免疫疗法显示出希望,但有限的持续时间和患者部分需要组合策略. 整合这些方法为更多患者提供了治疗癌症治疗的途径.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症治疗方法 癌症治疗方法
背景情况:
- 癌症治疗的进步源于理解瘤突变和分子免疫学.
- 向疗法针对特定突变,在大多数患者中产生反应,但通常具有有限的持久性.
- 免疫疗法,像检查点抑制剂一样,利用T细胞的反应,在一小部分患者中实现持久的缓解.
研究的目的:
- 审查针对性治疗和癌症免疫学方面的进展.
- 建议将这两种治疗方式整合起来,以改善癌症治疗结果.
- 倡导增加对组合疗法研究的资金.
主要方法:
- 关于向癌症治疗的科学文献的综述.
- 关于分子免疫学和免疫检查点抑制剂的科学文献的综述.
- 分析当前的研究趋势和癌症治疗的未来方向.
主要成果:
- 向疗法在大多数具有特定突变的患者中提供临床反应.
- 免疫疗法通过调节抗瘤T细胞活性,在一小部分患者中实现持久反应.
- 目前的治疗策略在响应持续时间和患者群体方面存在局限性.
结论:
- 结合向疗法和免疫疗法是开发治愈癌症治疗的有希望的策略.
- 进一步的研究和资金对于优化组合疗法至关重要.
- 综合方法可以为更大比例的癌症患者提供持久的反应.
相关概念视频
01:27Tumor Immunotherapy
2.5K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.5K
02:57Targeted Cancer Therapies
9.2K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.2K
02:57Targeted Cancer Therapies
1.8K
1.8K
02:50Combination Therapies and Personalized Medicine
6.4K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.4K
02:50Combination Therapies and Personalized Medicine
1.9K
1.9K
01:30Cancer Vaccines
1.4K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.4K