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蛋白质结构. 蛋白质结构. 在核酸加工酶中直接观察结构功能关系

Matthew J Comstock1, Kevin D Whitley1, Haifeng Jia2

  • 1Department of Physics, Center for the Physics of Living Cells, and Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

Science (New York, N.Y.)
|April 18, 2015
PubMed
概括

研究人员开发了一种新的单分子方法,直接将蛋白质结构和功能联系起来. 这项技术揭示了UvrDDNA修复酶中的两个不同的DNA解活动和构造状态.

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Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
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