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酶架构:优化过渡状态稳定从一个阴离子-二离子对

Archie C Reyes1, Astrid P Koudelka1, Tina L Amyes1

  • 1Department of Chemistry, University at Buffalo, SUNY, Buffalo, New York 14260-3000, United States.

Journal of the American Chemical Society
|April 18, 2015
PubMed
概括

糖3-酸脱酶 (GPDH) 使用基质结合能量来稳定过渡状态. 突变揭示了GPDH如何通过静电相互作用积极稳定过渡状态,从而提高催化效率.

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