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Updated: Apr 14, 2026

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聚素-1 是一种心肌细胞机械传感器,控制L型Ca2+通道蛋白稳定性

Zully Pedrozo1, Alfredo Criollo1, Pavan K Battiprolu1

  • 1From Division of Cardiology, Department of Internal Medicine (Z.P., A.C., P.K.B., C.R.M., N.J., X.L., B.A.R., T.G.G., S.L., J.A.H.) and Department of Molecular Biology (B.A.R., J.A.H.), UT Southwestern Medical Center, Dallas, TX; Advanced Center for Chronic Diseases and Centro de Estudios Moleculares de la Célula, Facultad de Medicina & Facultad de Ciencias Químicas y Farmacéuticas, Santiago, Chile (Z.P., A.C.-F., C.F., S.L.); Instituto de Ciencias Biomédicas, Facultad de Medicina (Z.P., S.L.) and Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología (A.C.), Universidad de Chile, Santiago; and Departments of Cellular and Molecular Physiology (M.J.C.), Internal Medicine (S.S.), and Genetics (S.S.), Yale University School of Medicine, New Haven, CT.

Circulation
|April 19, 2015
PubMed
概括

聚素-1 (PC-1) 作为心脏机械传感器,调节L型通道活性,防止心脏缩. PC-1稳定了一个关键的通道蛋白,对心肌生长至关重要.

关键词:
心脏病巨大的心脏病.机械传导,细胞传导.

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