阴道感觉神经元亚型,以差异化控制呼吸
Rui B Chang1, David E Strochlic1, Erika K Williams1
1Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Cell
|April 21, 2015
概括
研究人员在小鼠中发现了两个不同的迷走神经神经元组,这些神经元控制呼吸. 一组 (P2ry1) 停止呼吸,而另一组 (Npy2r) 导致快速,浅呼吸,揭示了呼吸的特定神经通路.
科学领域:
- 神经科学是一个神经科学.
- 呼吸系统生理学 呼吸系统生理学
- 自主神经系统研究 自主神经系统研究
背景情况:
- 呼吸对于生存至关重要,并由神经回路精确调节.
- 迷走神经是肺和大脑之间呼吸控制的关键通信通道.
研究的目的:
- 识别和表征鼠标迷走神经内不同的神经元群体,影响呼吸功能.
- 为了阐明这些已识别的 afferent神经元的解剖学连接和生理作用.
主要方法:
- 利用基因引导的解剖绘图来追踪小鼠的阴道 afferent 投射.
- 采用光遗传学来刺激特定的神经元群 (P2ry1和Npy2r) 并观察对呼吸的影响.
- 基于纤维传导速度 (A纤维与C纤维) 和细胞点的不同的神经元亚型.
主要成果:
- 确定了两种不同的状 afferent 种群:P2ry1 (主要是快速导导的 A 纤维) 和Npy2r (主要是缓慢导导的 C 纤维).
- P2ry1神经元刺激肺内分泌细胞,它们的刺激急性地使呼吸沉默,导致呼吸停止.
- Npy2r神经元刺激导致快速,浅呼吸;人口也没有影响心率或胃压力.
结论:
- 迷走神经包括可遗传定义的,交织在一起的感觉神经元,作为呼吸控制的独特标记线.
- 这些神经元群体具有独特的解剖目标,对呼吸产生相反的生理效应.
- 这一发现为通过特定的管道对神经调节呼吸的精细理解提供了帮助.
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