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Updated: Apr 14, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

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在人类遗传疾病中广泛存在的宏分子相互作用扰乱

Nidhi Sahni1, Song Yi1, Mikko Taipale2

  • 1Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science (CEGS), Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

Cell
|April 25, 2015
PubMed
概括

大多数疾病突变不会破坏蛋白质折叠,而是改变特定的蛋白质相互作用或DNA结合. 这些有针对性的变化,而不是广泛的损害,通常会导致不同的疾病表型.

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