前庭动和ST段升高风险与非ST段升高心肌梗塞风险:社区中的动脉样硬化风险 (ARIC) 研究研究
Elsayed Z Soliman1, Faye Lopez2, Wesley T O'Neal2
1From Epidemiological Cardiology Research Center, Department of Epidemiology and Prevention (E.Z.S., Z.-M.Z.), Department of Internal Medicine, Section on Cardiology (E.Z.S.), and Department of Internal Medicine (W.T.O.), Wake Forest School of Medicine, Winston Salem, NC; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (F.L., L.B., A.A.); Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis (L.Y.C.); Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill (L.L.); and Department of Medicine, University of Vermont, Burlington (M.C.). esoliman@wakehealth.edu.
心房动 (AF) 增加了心肌梗塞 (MI) 的风险,特别是非ST段升高MI (NSTEMI),特别是在女性中. 这一发现突显了心血管疾病机制中的潜在性别差异.
科学领域:
- 心脏病学 心脏病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 心房动 (AF) 与心肌梗塞 (MI) 的更高风险有关.
- 这种关联的潜在机制仍然不清楚.
- 调查AF和特定MI类型 (STEMI与NSTEMI) 之间的关系可能会提供有关机制的见解.
研究的目的:
- 检查心房动 (AF) 和发生心肌梗塞 (MI) 之间的关联.
- 确定这种关联是否在ST段高度MI (STEMI) 和非ST段高度MI (NSTEMI) 之间有所不同.
- 探索AF-MI关系中的潜在性别差异.
主要方法:
- 从社区动脉样硬化风险 (ARIC) 研究中分析了14462名参与者,在基线没有冠状动脉心脏病.
- 通过心电图和医院记录对发生的MI和AF识别的随访,平均为21.6年.
- 用多变量调整的考克斯比例危险模型来评估关联,并对性别差异进行相互作用分析.
主要成果:
- 心房动 (AF) 与整体心脏病发作风险增加63%有关.
- 这种关联对于非ST段升高MI (NSTEMI) 是显著的,但对于ST段升高MI (STEMI) 则不是.
- 在女性中,AF和MI (总和NSTEMI) 之间的联系明显比男性更强.
结论:
- 心房动与发生心肌梗塞的风险增加有关.
- 这种关联与非ST段高度MI (NSTEMI) 特别相关.
- 与男性相比,女性在AF和MI之间表现出更强烈的关联.
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