DrosophilaN6-DNA

Guoqiang Zhang1, Hua Huang2, Di Liu2

  • 1State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

Cell
|May 5, 2015
PubMed
概括

在Drosophila中发现了DNAN(6) -甲基亚丁 (6mA) 修饰,在发育过程中由DMAD脱甲基酶调节. 这种DNA修饰对于抑制转子体和控制高级真核生物的发育至关重要.

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RNA Editing

RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
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