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Updated: Apr 13, 2026

Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation
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基因素H3.3对于胚胎干细胞内源性逆转录病毒元素沉默是必需的

Simon J Elsässer1,2, Kyung-Min Noh3, Nichole Diaz3

  • 1MRC Laboratory of Molecular Biology, Francis Crick Ave, Cambridge, CB2 0QH, United Kingdom.

Nature
|May 5, 2015
PubMed
概括

基因组变异H3.3控制胚胎干细胞内源性逆转录病毒元素 (ERV) 逆转录. 它的沉积与KAP1和ESET联系在一起,建立了一个独特的异染色体状态,使ERV沉默,防止基因组不稳定.

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