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Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass
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通过CDC42对戈尔基的双向COPI运输的协调监管

Seung-Yeol Park1, Jia-Shu Yang1, Angela B Schmider2

  • 11] Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA [2] Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature
|May 7, 2015
PubMed
概括

毛皮蛋白I (COPI) 复合体将蛋白质分类成戈尔吉管,补充水槽成熟. CDC42调节了这种运输和膜曲率,这对于细胞蛋白质分类至关重要.

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While it is unclear how molecules move between adjacent Golgi cisternae, it is apparent that the molecules move from cis- cisterna, the entry face, to the trans- cisterna, the exit face. Experiments initially suggested vesicles that bud from one cisterna and fuse with the next cisterna to transport proteins between the cisternae. This vesicular transport model describes the Golgi apparatus as a relatively static structure with a unique enzyme composition in each cisterna. Molecules are...
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