CD11c+树突细胞通过互白素-17A加速拒绝老年心脏移植
Rupert Oberhuber1, Timm Heinbokel1, Hector Rodriguez Cetina Biefer1
1From Transplantation Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.O., T.H., H.R.C.B., K.H., K.E., H.U., M.Q., F.V., F.K., B.S., A.E., S.G.T.); Department of Visceral, Transplant, and Thoracic Surgery, Center for Operative Medicine, Innsbruck Medical University, Austria (R.O.); Institute of Medical Immunology (T.H.) and Department for General, Visceral, Transplant, Vascular, and Thorax Surgery (J.P.), Charité-Universitätsmedizin Berlin, Germany; Clinic for Cardiovascular Surgery, University Hospital Zurich, Switzerland (H.R.C.B., M.J.W.); Transplantation Research Center, Brigham and Women's Hospital and Children's Hospital Boston, Harvard Medical School, Boston, MA (O.B., R.A.); Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (O.B.); Division of Transplantation, Department of Surgery, Medical University of Vienna, Austria (K.H.); Rodent Histopathology Core, Harvard Medical School, Boston, MA (R.T.B.); Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan (R.T.B.); Department of Visceral, Transplantation, Thoracic, and Vascular Surgery, University Hospital of Leipzig, Germany (M.Q., F.K.); and Division of Transplant Surgery, Department of Surgery, Erasmus MC-University Medical Center, Rotterdam, The Netherlands (B.S.).
较老的捐赠器官导致移植存活率较差,原因是免疫反应增加. 向介质素-17A可能会在使用较老的捐赠器官进行移植时改善结果.
科学领域:
- 免疫学 免疫学 免疫学
- 移植科学 移植科学
- 老年学是一门学科.
背景情况:
- 对捐献器官的需求不断增加,导致更多地使用老年捐献器官.
- 较老的捐赠器官与不良的移植结果有关,这构成了重大挑战.
研究的目的:
- 调查捐赠者年龄对固体器官移植结果的影响.
- 阐明在移植中依赖年龄的非免疫反应背后的机制.
主要方法:
- 利用小鼠心脏移植模型来评估移植的存活率.
- 分析了免疫细胞种群,细胞因子生产和T细胞反应.
- 研究了CD11c+树突细胞和白素-17A在移植拒绝中的作用.
主要成果:
- 与年轻的捐赠心脏相比,老年捐赠心脏的移植存活能力受到损害.
- 年龄相关的非免疫反应是由移植的CD11c+树突细胞调解的.
- 观察到受体免疫细胞增加了17A型白内素的产生.
结论:
- 老捐赠者CD11c+树突细胞在年龄依赖的非免疫反应中发挥着关键作用.
- 升高的17A介质素水平有助于加速移植排斥.
- 准17A介质素是一个潜在的治疗策略,可以改善老年捐赠器官的治疗结果.
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