对转录网络的理解
Trevor R Sorrells1, Alexander D Johnson1
1Department of Biochemistry & Biophysics and Department of Microbiology & Immunology, Tetrad Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.
Cell
|May 11, 2015
概括
细胞转录网络中的共同特征可能不是适应性的. 相反,这些相似之处可能来自于抵抗最小的进化路径,有利于更简单的结构.
科学领域:
- 进化生物学是进化的生物学.
- 系统生物学 系统生物学
- 基因组学就是基因组学.
背景情况:
- 细胞转录调节网络显示保存的特征,如基因数量,重叠连接和功能冗余.
- 这些相似之处往往被解释为由自然选择驱动的适应.
研究的目的:
- 提出并讨论转录监管网络中观察到的共同点的替代假设.
- 挑战网络复杂性仅仅是适应性进化的产物这一假设.
主要方法:
- 在远距离相关的真核生物中对转录调节网络的比较分析.
- 关于进化轨迹和最小阻力原理的理论讨论.
主要成果:
- 在真核生物之间转录网络中发现了惊人的相似之处,包括基因数量,连接性和冗余性.
- 提出了支持这些共同特征源于进化"最小阻力"路径的假设的证据.
结论:
- 转录网络中的结构共同点可能不是直接的适应,而是进化约束的新兴特性.
- 容易形成的进化轨迹可以解释这些复杂的生物网络的保存特征.
相关概念视频
Transcription
36.6K
Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
36.6K
Transcription
160.4K
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
160.4K
Transcription
3.5K
3.5K
Transcription
48.1K
48.1K
Transcription Factors
84.3K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
84.3K
Transcription Factors
27.4K
27.4K


