杆衍生的形生存因子通过刺激有氧糖解促进形生存
Najate Aït-Ali1, Ram Fridlich1, Géraldine Millet-Puel1
1INSERM, U968, 75012 Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 968, Institut de la Vision, 75012 Paris, France; CNRS, UMR_7210, 75012 Paris, France.
Cell
|May 11, 2015
概括
杆衍生状活力因子 (RdCVF) 通过与Basigin-1 (BSG1) 结合,增加葡萄糖吸收并通过有氧糖解支持状活力,从而保护 retinitis pigmentosa 中的状活力因子.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 分子生物学分子生物学
背景情况:
- 皮质视网膜炎 (RP) 导致二次形变性和失明.
- 杆衍生圆活力因子 (RdCVF) 是RP的潜在治疗剂.
- 在RP中RdCVF的保护机制尚待阐明.
研究的目的:
- 研究RdCVF保护从RP中退化的分子机制.
- 在光受体细胞上识别RdCVF的受体.
主要方法:
- 研究了RdCVF与光受体细胞表面蛋白的相互作用.
- 利用基于细胞的测试来测量葡萄糖吸收和糖解.
- 采用RP的小鼠模型来评估RdCVF的治疗疗效.
主要成果:
- RdCVF特别与光受体细胞上的Basigin-1 (BSG1) 结合.
- BSG1促进葡萄糖输送器GLUT1的相互作用,增强葡萄糖进入体.
- 在RP模型中,RdCVF诱导的葡萄糖代谢对形生存至关重要.
结论:
- 通过激活BSG1-GLUT1通路来促进葡萄糖代谢,RdCVF保护RP中的.
- 这项研究揭示了一种新的神经保护机制,涉及刺激有氧糖解.
- 针对RdCVF-BSG1-GLUT1轴为RP和相关视网膜退化提供了一个有希望的治疗策略.
相关概念视频
Glycolysis
1.7K
Glycolysis, the Embden-Meyerhof pathway, is a central metabolic pathway involved in glucose catabolism. It is highly conserved across most organisms, reflecting its fundamental role in cellular energy production. This process occurs in the cytoplasm and can function both in the presence and absence of oxygen, making it versatile for various organisms and environmental conditions.Stages of GlycolysisGlycolysis is a ten-step pathway that converts glucose into pyruvate, generating a net gain of...
1.7K
What is Glycolysis?
176.9K
Overview
Cells make energy by breaking down macromolecules. Cellular respiration is the biochemical process that converts "food energy" (from the chemical bonds of macromolecules) into chemical energy in the form of adenosine triphosphate (ATP). The first step of this tightly regulated and intricate process is glycolysis. The word glycolysis originates from the Latin glyco (sugar) and lysis (breakdown). Glycolysis serves two main intracellular functions: generating ATP and generating...
Cells make energy by breaking down macromolecules. Cellular respiration is the biochemical process that converts "food energy" (from the chemical bonds of macromolecules) into chemical energy in the form of adenosine triphosphate (ATP). The first step of this tightly regulated and intricate process is glycolysis. The word glycolysis originates from the Latin glyco (sugar) and lysis (breakdown). Glycolysis serves two main intracellular functions: generating ATP and generating...
176.9K
Outcomes of Glycolysis
107.1K
Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.1K
Energy-releasing Steps of Glycolysis
146.8K
Glycolysis is divided into two phases based on whether energy is utilized or released. While the first phase consumes ATP, the second phase produces energy in the form of ATP and NADH. The energy is released over a sequence of reactions that turns G3P into pyruvate. The energy-releasing phase—steps 6-10 of glycolysis—occurs twice, once for each of the two 3-carbon sugars produced during steps 1-5 of the first phase.
The first energy-releasing step—the 6th step of glycolysis...
The first energy-releasing step—the 6th step of glycolysis...
146.8K
Energy-requiring Steps of Glycolysis
171.5K
Glucose is the source of nearly all energy used by organisms. The first step of converting glucose into usable energy is called glycolysis. Glycolysis occurs in the cytosol of the cell over two phases: an energy-requiring phase and an energy-releasing phase. Over the first three steps, glucose is converted into different forms and attached to two phosphate groups donated by two ATP molecules, resulting in an unstable sugar. In the next two stages, the unstable sugar splits into two sugar...
171.5K
The Eukaryotic Promoter Region
18.8K
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences. The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
18.8K


