通过Ni-催化C-OMe裂对乙烯的ipso-borylation进行了催化
Cayetana Zarate1, Rubén Manzano1, Ruben Martin1,2
1†Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans 16, 43007 Tarragona, Spain.
Journal of the American Chemical Society
|May 16, 2015
概括
这项研究引入了一种新的催化化的乙烯,有效地分裂碳氧键. 这种反应提供了可调节的位点选择性,使各种合成应用成为可能.
科学领域:
- 有机金属化学 有机金属化学
- 合成有机化学 合成有机化学
背景情况:
- 乙烯是药品和材料中普遍存在的结构图案.
- 对于功能化乙烯的高效方法,特别是通过C-O键裂解,是非常受欢迎的.
- 现有的玻利化方法往往缺乏选择性向同一分子内的不同C-O键的能力.
研究的目的:
- 开发一种新的催化方法,用于乙烯的ipso-borylation.
- 为了实现选择性裂变,要么是基C(sp2) -OMe,要么是基C(sp3) -OMe键.
- 为了证明开发的玻利化反应的广泛适用性和可调节的选择性.
主要方法:
- 催化交叉合反应.催化交叉合反应.
- 用各种乙烯作为基质.
- 使用不同的试剂来控制位点选择性.
- 反应条件的优化,包括催化剂负荷,温度和溶剂.
主要成果:
- 通过C{sp2}-OMe和C{sp3}-OMe键断裂成功实现了基乙烯的ipso-borylation.
- 反应表现出广泛的基质范围,耐受多样化的功能组.
- 证明了精致的位点选择性,可以通过选择试剂轻松控制.
- 采用了轻度反应条件,提高了该方法的实用性.
结论:
- 开发了一种多功能Ni-催化阿里尔的ipso-borylation.
- 该方法为选择性C-O债券功能化提供了一个强大的工具.
- 切换位点选择性的能力为复杂分子合成提供了显著的优势.
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