尿路结肠的成年人的医疗驱逐疗法:一个多中心,随机,安慰剂控制的试验
Robert Pickard1, Kathryn Starr2, Graeme MacLennan2
1Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
Lancet (London, England)
|May 23, 2015
概括
坦素和尼菲迪平并没有改善尿道结肠的石头通道. 这些平滑肌肉松药物在标准临床环境中无效,在预期管理方面没有比安慰剂更有好处.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 之前的元分析表明,坦苏洛辛和尼菲迪平有助于尿道石的通过.
- 确定需要具有广泛纳入标准的高质量试验.
研究的目的:
- 为了测试tamsulosin和nifedipine在尿路结肠的标准临床护理环境中的有效性.
- 为了确定这些药物是否减少了进一步干预石头清理的需要.
主要方法:
- 一个多中心,随机,安慰剂对照试验,涉及1167名尿道结石的成年人.
- 参与者每天接受tamsulosin,nifedipine或安慰剂,长达4周.
- 主要结局是参与者在4周内不需要进一步干预的比例.
主要成果:
- 80%的安慰剂组,81%的松素组和80%的尼菲迪平组不需要进一步干预 (分别为p=0.73和p=0.88).
- 在活性治疗和安慰剂之间没有发现显著差异 (p=0.78).
- 严重的不良事件是罕见的,在不同组之间是可比的.
结论:
- 坦素和尼菲迪平在减少尿路结肠患者进一步治疗石头清除的需要方面没有效果.
- 这些药物对尿道结石的预期管理没有任何好处.
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