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Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence
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通过利用瘤对稳定突变p53的依赖来改善存活率,以进行治疗

E M Alexandrova1, A R Yallowitz1, D Li1

  • 1Department of Pathology, Stony Brook University, Stony Brook, New York 11794, USA.

Nature
|May 27, 2015
PubMed
概括

误解突变p53 (mutp53) 蛋白质驱动癌症的进展和化学抵抗. 针对由HSP90/HDAC6稳定的mutp53,有效地减少瘤生长,并在临床前模型中延长存活时间.

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