大豆异黄补充剂对肺功能和控制不良喘患者的临床结果的影响:一项随机临床试验
Lewis J Smith1, Ravi Kalhan1, Robert A Wise2
1Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
JAMA
|May 27, 2015
概括
在24周的试验中,大豆异黄补充剂没有改善肺功能或喘控制. 这项研究表明,大豆异黄不是对控制不良的喘有效的治疗方法.
科学领域:
- 肺部病理学 肺部病理学
- 临床营养学 临床营养学
- 药理学 药理学是指药理学的学科.
背景情况:
- 豆类异黄补充剂正在被用于慢性疾病管理,但其有效性的证据有限,特别是在喘中.
- 以前的数据表明,大豆异黄补充剂对控制不良的喘患者有潜在的益处.
研究的目的:
- 为了评估大豆异黄补充剂在改善喘控制的有效性,在青少年和成年患者中控制不良的喘.
- 评估大豆异黄对喘患者肺功能,症状和炎症标志物的影响.
主要方法:
- 一个多中心,随机,双盲,安慰剂控制的试验,涉及386名参与者 (12岁以上) 患有症状,控制不良的喘.
- 参与者每天接受100毫克大豆异黄或安慰剂,持续24周.
- 主要结局是强迫呼吸量在第一秒内发生的变化 (FEV1);次要结局包括症状得分,喘控制测试结果和炎症生物标志物.
主要成果:
- 在24周 (P=.36) 时,大豆异黄组 (0.01L) 和安慰剂组 (0.03L) 之间没有观察到主要结局 (bronchodilator前FEV1的变化) 的显著差异.
- 二级结局,包括症状评分,喘控制不良的情节和呼出的氧化水平,同样没有显示与安慰剂相比,大豆异黄补充剂的显著改善.
- 在大豆异黄组中,血基尼斯水平显著增加,证实了补充剂的吸收.
结论:
- 补充大豆异黄并没有改善成年人和患有控制不良喘的儿童的肺功能或临床喘控制.
- 这些发现不支持使用大豆异黄补充剂作为治疗控制不良喘患者的方法.
- 可能需要进一步的研究来探索大豆异黄的其他潜在应用或配方,但目前的证据不支持它们用于喘管理.
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