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相关概念视频

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

7.0K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
7.0K
Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
9.3K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

4.3K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

5.6K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
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相关实验视频

Updated: Apr 11, 2026

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
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亚临床甲状腺功能障碍和骨折风险:一个元分析.

Manuel R Blum1, Douglas C Bauer2, Tinh-Hai Collet3

  • 1Department of General Internal Medicine, Inselspital, Bern University Hospital, Bern, Switzerland.

JAMA
|May 27, 2015
PubMed
概括

亚临床甲状腺功能障碍,而不是甲状腺功能障碍,增加骨折风险,特别是部骨折. 较低的甲状腺刺激激素 (TSH) 水平与较高的骨折率相关,因此需要进一步研究治疗的有效性.

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Assessment of Bone Fracture Healing Using Micro-Computed Tomography
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科学领域:

  • 内分泌学 在内分泌学.
  • 骨健康 骨健康 骨健康
  • 流行病学 流行病学

背景情况:

  • 亚临床甲状腺功能障碍与骨折的联系尚未得到充分证实.
  • 缺乏研究这种关联的临床试验.

研究的目的:

  • 为了确定亚临床甲状腺功能障碍和骨折之间的关联.
  • 具体检查部,非脊柱,脊柱和任何骨折类型.

主要方法:

  • 对前性队列研究进行系统审查和元分析.
  • 分析了13个队列 (70,298名参与者) 的数据.
  • 根据TSH水平,甲状腺功能被分类为euthyroidism,亚临床甲状腺功能障碍和亚临床甲状腺功能障碍.

主要成果:

  • 亚临床甲状腺功能障碍与关节骨折风险 (HR 1.36) 和任何骨折风险 (HR 1.28) 的增加有关.
  • 非常低的TSH水平 (<0.10 mIU/L) 显示部,任何骨和脊柱骨折的风险显著增加.
  • 在亚临床甲状腺功能低下症和骨折风险之间没有发现显著的关联.

结论:

  • 亚临床甲状腺功能障碍与骨折,特别是部骨折的风险更高有关.
  • 这种风险在较低的TSH水平和内源性亚临床甲状腺功能障碍症中更为明显.
  • 需要进一步的研究来探索是否治疗亚临床甲状腺功能障碍症可以减轻骨折风险.