一个前额头 - - thalamo - - 海马回路用于目标定向的空间导航
Hiroshi T Ito1, Sheng-Jia Zhang1, Menno P Witter1
1Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres gate 9, MTFS, 7491 Trondheim, Norway.
Nature
|May 29, 2015
概括
一个涉及核团聚的前额頭-甲状腺电路对于海马体来表示导航轨迹至关重要. 这一途径使大脑能够在目标定向导航期间绘制未来的路径.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 系统神经科学 系统神经科学
背景情况:
- 空间导航依赖于了解当前和未来的位置.
- 海马神经元编码位置和路径轨迹,但目标方向信息的来源尚不清楚.
研究的目的:
- 在导航过程中识别负责海马体轨迹表示的神经回路.
- 阐明前额前 - thalamic通道在目标导向空间行为中的作用.
主要方法:
- 电生理学记录在老鼠观察神经元发射模式.
- 病变和光遗传沉默技术来破坏特定的神经通路.
- 对中部前额叶皮质,核团聚和海马体的轨迹依赖性射击的分析.
主要成果:
- 在中部前额叶皮质,核团聚和CA1海马体中确定了轨迹依赖的神经元发射.
- 核心团聚的破坏显著损害了CA1区域的轨迹依赖性发射.
- 缺少核团聚输入的CA3海马区域显示了最小的轨迹依赖活动.
结论:
- 从中部前额叶皮层到核团聚的投影对于表示未来导航路径至关重要.
- thalamus,特别是核聚会,作为一个关键的中继在导航皮质通信.
- 这一前额前 - - thalamic - - 海马回路对于目标定向的空间导航至关重要.
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