耐化学药性卵巢癌的全基因组表征

Ann-Marie Patch1, Elizabeth L Christie2, Dariush Etemadmoghadam3

  • 11] Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4067, Australia [2] QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.

Nature
|May 29, 2015
PubMed
概括

高度血清性卵巢癌 (HGSC) 显示生存率几乎没有改善. 全基因组测序揭示了基因破裂使瘤抑制剂失活,并有助于化学疗法耐药性,在初级耐药性疾病中具有CCNE1放大.

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