相关实验视频

Updated: Apr 11, 2026

Specificity Analysis of Protein Lysine Methyltransferases Using SPOT Peptide Arrays
08:48

Specificity Analysis of Protein Lysine Methyltransferases Using SPOT Peptide Arrays

Published on: November 29, 2014

14.6K

使用性环氧基抑制剂对20S蛋白质体基质偏好的系统分析

Eva M Huber1, Gerjan de Bruin2, Wolfgang Heinemeyer1

  • 1†Center for Integrated Protein Science at the Department Chemie, Lehrstuhl für Biochemie, Technische Universität München, 85748 Garching, Germany.

Journal of the American Chemical Society
|May 29, 2015
PubMed
概括

这项研究揭示了使用环氧基抑制剂的蛋白质酶体基质特异性,指导了针对癌症等疾病的向蛋白质酶体抑制剂的开发.

更多相关视频

Use of Recombinant Fusion Proteins in a Fluorescent Protease Assay Platform and Their In-gel Renaturation19:23

Use of Recombinant Fusion Proteins in a Fluorescent Protease Assay Platform and Their In-gel Renaturation

Published on: January 16, 2019

9.9K
The Determination of Protease Specificity in Mouse Tissue Extracts by MALDI-TOF Mass Spectrometry: Manipulating PH to Cause Specificity Changes09:47

The Determination of Protease Specificity in Mouse Tissue Extracts by MALDI-TOF Mass Spectrometry: Manipulating PH to Cause Specificity Changes

Published on: May 25, 2018

7.2K

相关概念视频

The Proteasome Structure01:17

The Proteasome Structure

The ubiquitin-proteasome pathway is a well-known mechanism utilized by eukaryotic cells to remove cytoplasmic proteins that are misfolded, damaged, or no longer needed. In this pathway, the protein that needs to be eliminated undergoes a process called ubiquitination, where a chain of ubiquitin molecules is attached to the 48th lysine residue of the target protein. This ubiquitin modification helps the proteasome distinguish between a target protein and a healthy protein.
The proteasome is an...
2.2K