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相关概念视频

Anatomy of the Brain: Major Regions01:20

Anatomy of the Brain: Major Regions

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The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect...
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Cerebrum: Anatomical Overview I01:26

Cerebrum: Anatomical Overview I

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The main and largest component of the human brain is the cerebrum. The cerebrum consists of two main parts: the cerebral cortex, an outer layer with wrinkles or folds known as gyri and shallow grooves called sulci, and a deeper region beneath it. The cerebrum divides into two distinct hemispheres and contains five different lobes: the frontal, parietal, temporal, occipital, and insula. The central sulcus separates the frontal and parietal lobes and two functionally important gyri — the...
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Organization of the Brain01:30

Organization of the Brain

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The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
3.9K
Anatomy of the Brain: Ventricles01:18

Anatomy of the Brain: Ventricles

11.6K
There are hollow fluid-filled cavities known as ventricles deep inside the human brain. There are two lateral ventricles, one in each cerebral hemisphere, and each has three different projections — the anterior, inferior, and posterior horns visible from the lateral side. A thin membrane called the septum pellucidum separates the two lateral ventricles. The slender third ventricle in the diencephalon is connected to each lateral ventricle via a channel called the interventricular foramen.
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Cerebrum: Anatomical Overview II01:11

Cerebrum: Anatomical Overview II

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Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
6.1K
Overview of Anatomy and Physiology01:24

Overview of Anatomy and Physiology

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Human anatomy is the scientific study of the body's structures. Some of these structures are very small and can only be observed and analyzed with the assistance of a microscope. Other larger structures can readily be seen, manipulated, measured, and weighed. The word "anatomy" comes from a Greek root that means "to cut apart." Human anatomy was first studied by observing the body's exterior and the wounds of soldiers and other injuries. Later, physicians were allowed to...
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相关实验视频

Updated: Apr 11, 2026

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions
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Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

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人类微处理器的功能解剖学

Tuan Anh Nguyen1, Myung Hyun Jo2, Yeon-Gil Choi1

  • 1Center for RNA Research, Institute for Basic Science, Seoul 151-742, Korea; School of Biological Sciences, Seoul National University, Seoul 151-742, Korea.

Cell
|June 2, 2015
PubMed
概括
此摘要是机器生成的。

含有DROSHA和DGCR8的微处理器精确地处理了primiRNAs. 这个复合体通过识别特定的RNA动机和测量关键距离来确保正确的微RNA (miRNA) 成熟.

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Exploring Deep Space - Uncovering the Anatomy of Periventricular Structures to Reveal the Lateral Ventricles of the Human Brain
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Exploring Deep Space - Uncovering the Anatomy of Periventricular Structures to Reveal the Lateral Ventricles of the Human Brain

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A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging
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A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging

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相关实验视频

Last Updated: Apr 11, 2026

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions
08:06

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Published on: February 15, 2021

58.8K
Exploring Deep Space - Uncovering the Anatomy of Periventricular Structures to Reveal the Lateral Ventricles of the Human Brain
17:13

Exploring Deep Space - Uncovering the Anatomy of Periventricular Structures to Reveal the Lateral Ventricles of the Human Brain

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A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging
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科学领域:

  • 分子生物学分子生物学
  • 在RNA生物学,RNA生物学.
  • 生物化学 生物化学

背景情况:

  • 微RNA (miRNA) 成熟是基因调节的一个关键过程.
  • 微处理器复合体,包括RNase III DROSHA及其辅因子DGCR8,启动了miRNA的成熟.
  • 了解微处理器对primiRNA识别的精确机制对于理解miRNA生物发生是必不可少的.

研究的目的:

  • 阐明人类微处理器复合体识别primiRNAs的结构和功能机制.
  • 为了确定微处理器综合体的固体测量和最小的功能组件.
  • 为了确定涉及到pri-miRNA处理的特定识别元素和相互作用.

主要方法:

  • 人类微处理器复合物的复合利用纯化的重组DROSHA和DGCR8蛋白质.
  • 生物化学测试以确定复杂的静脉测量和确定最小的功能核心.
  • 对蛋白质-RNA相互作用的分析和对primiRNAs特定识别动机的识别.

主要成果:

  • 人类的微处理器是一个大约364kDa的异构分子复合体,由一个DROSHA和两个DGCR8分子组成.
  • 一个最小的功能核心由DROSHA和来自DGCR8的23氨基酸组成.
  • 德罗莎作为一个统治者,从基底ssRNA-dsRNA连接处测量11bp,而DGCR8绑定干和顶点元素.
  • 根据DROSHA和DGCR8分别对基底UG和基UG图案的特定识别,确保了正确的复杂方向和准确的处理.

结论:

  • 这项研究澄清了微处理器复合体对pri-miRNA处理的机制,解决了以前的争议.
  • 提出了对pri-miRNA处理的详细模型,突出了DROSHA和DGCR8在基质识别和裂变中的作用.
  • 这些发现为miRNA生物发生的调节及其对细胞功能的影响提供了基本的见解.