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Updated: Apr 11, 2026

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对于JAK-STAT信号传递的酶独立小分子抑制

Danny Hung-Chieh Chou1, Amedeo Vetere, Amit Choudhary2

  • 1‡Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.

Journal of the American Chemical Society
|June 5, 2015
PubMed
概括

小分子BRD0476通过USP9X抑制JAK-STAT通路来保护胰腺细胞,而不是通过抑制JAK激酶活性来保护胰腺细胞. 这表明USP9X是调节炎症的新目标.

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