由女性激素对感官知觉的循环调节改变了行为
Sandeepa Dey1, Pablo Chamero2, James K Pru3
1Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA.
Cell
|June 6, 2015
概括
雌性小鼠表现出状态依赖的感官处理. 孕激素在消化期暂时沉默特定的激素检测神经元,改变感官输入和行为.
科学领域:
- 神经科学是一个神经科学.
- 感官生物学 感官生物学
- 动物行为 动物行为
背景情况:
- 女性的生殖状态影响行为,通过对大脑起作用的激素来调解行为.
- 排卵周期对感官处理的影响,特别是费洛蒙检测,仍然在很大程度上未被探索.
研究的目的:
- 为了调查雌性小鼠的传入感官活动是否在排卵周期内有所不同.
- 确定雌性循环是否调节了鼻嗅觉神经元 (VSN) 检测男性发射的费洛蒙.
主要方法:
- 雌性小鼠在雌性周期的不同阶段对VSN的电生理记录.
- 药理学操纵以评估孕激素在VSN沉默中的作用.
- 确定参与孕激素介导的VSN失活的信号通路.
主要成果:
- 雌性小鼠中的VSN在期对特定的雄性费罗蒙配体有选择性"盲目",但在期对其有反应.
- 孕激素是一种关键的女性性类固醇,它调解了这种暂时的VSN沉默.
- 检测非雌激素配体的VSN,例如来自猫的VSN,无论雌激素周期的阶段如何,都保持活跃.
结论:
- 内在的生理状态,特别是性循环,可以动态调节感官输入.
- 孕激素选择性地准并禁用特定的激素反应性VSN子集,表明生理学和感官处理之间存在直接联系.
- 这种选择性感官门允许雌性小鼠在状态特定的行为反应.
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