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Updated: Apr 11, 2026

Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells
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Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells

Published on: January 11, 2019

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一个独特的基因调节网络将人类生殖系表观基因组重置为发育

Walfred W C Tang1, Sabine Dietmann2, Naoko Irie1

  • 1Wellcome Trust Cancer Research UK Gurdon Institute, Tennis Court Road, University of Cambridge, Cambridge CB2 1QN, UK; Department of Physiology, Development and Neuroscience, Downing Street, University of Cambridge, Cambridge CB2 3EG, UK; Wellcome Trust-Medical Research Council Stem Cell Institute, Tennis Court Road, University of Cambridge, Cambridge CB2 3EG, UK.

Cell
|June 6, 2015
PubMed
概括

人类生殖系表观基因组重编程是独一无二的,具有特定的基因网络驱动DNA脱甲基和染色质变化. 一些元素抵抗脱甲基化,这表明跨代表观遗传可能影响发育和疾病.

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