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Updated: Apr 11, 2026

Isolation of Soluble and Insoluble PrP Oligomers in the Normal Human Brain
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人类质蛋白的天然变体完全防止了质疾病

Emmanuel A Asante1, Michelle Smidak1, Andrew Grimshaw1

  • 1MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London WC1N 3BG, UK.

Nature
|June 11, 2015
PubMed
概括

G127V蛋白 (PrP) 变体对诸如 kuru 和 Creutzfeldt-Jakob 疾病 (CJD) 等蛋白疾病提供了完全的抵抗力. 这种变异也强烈抑制了其他子菌株的传播.

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