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从黄金中减少淘汰的化物依赖机制 (III)

Matthew S Winston1, William J Wolf1, F Dean Toste1

  • 1Department of Chemistry, University of California, Berkeley, California 94720, United States.

Journal of the American Chemical Society
|June 13, 2015
PubMed
概括

研究人员合成了新的有机金属化物复合物. 化物连接体的身份极大地影响了还原性消除中的反应性和选择性,Au(III) -X键强度是关键决定因素.

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A nucleophile can react with an alkyl halide to give the substitution product by displacing the halogen. Or it can function as a base to give the elimination product by deprotonation of the neighboring carbon to form an alkene. In an elimination reaction, the substrate loses two groups from adjacent carbons forming at least one π bond. The carbon attached to the halogen is called the α carbon, while the adjacent carbon is called the β carbon; hence, these reactions are called...
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