艾滋病毒-1疫苗. 由原生类包膜剪切剂诱导的HIV-1中和抗体
Rogier W Sanders1, Marit J van Gils2, Ronald Derking2
1Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065, USA. Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, Netherlands. jpm2003@med.cornell.edu rws2002@med.cornell.edu.
设计有效的HIV-1疫苗是很困难的. 与原生类似的信封糖蛋白修剪剂显示出诱导对抗性HIV-1菌株的中和抗体的前景.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 疫苗开发 疫苗开发
背景情况:
- 诱导中和抗体 (NAbs) 针对耐中和 (二级) HIV-1 菌株是疫苗设计中的一个主要障碍.
- 二级病毒是导致大多数人体HIV-1病毒传播的原因.
研究的目的:
- 为了评估与原生类型的HIV-1包膜糖蛋白trimers的免疫性.
- 为了确定这些trimers是否可以引起NAbs对2级HIV-1病毒.
主要方法:
- 具有原生构造的可溶性复合HIV-1包膜糖蛋白剪切剂 (BG505 SOSIP.664和B41 SOSIP.664) 被用作免疫原体.
- 通过测量对1级和2级病毒的NAb反应,对子和子进行免疫性评估.
主要成果:
- BG505 SOSIP.664三元体对子的序列匹配的二级病毒强烈诱导NAbs,对子的反应较弱.
- 这两种trimers都诱导了对1级病毒的交叉反应NAbs.
- 2级NAbs识别了构造性表位,其中一些与广泛中和抗体 (bNAbs) 重叠,而1级NAbs针对的是线性V3表位.
结论:
- 类似于原生HIV-1包膜糖蛋白的trimers是诱导NAbs对2级病毒的有效免疫原体.
- 这些trimers代表了开发HIV-1疫苗的有希望的战略,旨在引起bNAbs.
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