Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

11.0K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
11.0K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

2.6K
2.6K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

8.6K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
8.6K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

1.9K
1.9K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

6.3K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
6.3K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

2.1K
2.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Acupuncture does not work and has no place in science-based medicine.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Developing evidence-based, cost-effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities.

Molecular oncology·2025
Same author

A quality framework for cryopreserved rodent disease models: INFRAFRONTIER quality principles in EMMA archiving and distribution.

Mammalian genome : official journal of the International Mammalian Genome Society·2025
Same author

European cancer research requires renewed urgency.

Nature cancer·2025
Same author

Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression.

Science (New York, N.Y.)·2025
Same author

Strategies to reduce the cancer burden and improve access to effective and affordable cancer interventions in Europe.

Molecular oncology·2025

相关实验视频

Updated: Apr 9, 2026

The Soft Agar Colony Formation Assay
08:01

The Soft Agar Colony Formation Assay

Published on: October 27, 2014

114.5K

没有下降,瘤的风起?

Paul Krimpenfort1, Anton Berns2

  • 1Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121. 1066 CX Amsterdam, The Netherlands.

Cell
|June 20, 2015
PubMed
概括
此摘要是机器生成的。

在小鼠肠道瘤中恢复腺多样性胆固醇 (APC) 功能导致完全回归和正常细胞功能,即使有Kras和p53突变. 这突出了Wnt路径.

更多相关视频

Use of the TetON System to Study Molecular Mechanisms of Zebrafish Regeneration
10:22

Use of the TetON System to Study Molecular Mechanisms of Zebrafish Regeneration

Published on: June 25, 2015

11.3K
Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
08:10

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

Published on: December 14, 2015

11.9K

相关实验视频

Last Updated: Apr 9, 2026

The Soft Agar Colony Formation Assay
08:01

The Soft Agar Colony Formation Assay

Published on: October 27, 2014

114.5K
Use of the TetON System to Study Molecular Mechanisms of Zebrafish Regeneration
10:22

Use of the TetON System to Study Molecular Mechanisms of Zebrafish Regeneration

Published on: June 25, 2015

11.3K
Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
08:10

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

Published on: December 14, 2015

11.9K

科学领域:

  • 在瘤学瘤学.
  • 分子生物学分子生物学
  • 胃肠病学 胃肠病学

背景情况:

  • 肠道瘤通常是由关键细胞通路中断引起的.
  • 腺多样性胆固醇 (APC) 基因在调节细胞生长和分化方面发挥着至关重要的作用.
  • 在结直肠癌中,APC的突变很常见,导致不受控制的增殖.

研究的目的:

  • 调查恢复APC功能在已建立的肠道瘤中的治疗潜力.
  • 确定APC恢复是否可以诱导瘤回归并恢复正常的细胞表型.
  • 评估APC恢复对具有并发Kras和p53突变的瘤的影响.

主要方法:

  • 在小鼠模型中通过APC抑制诱导肠道瘤.
  • 在现有瘤中恢复APC功能.
  • 对瘤回归,细胞分化和干细胞功能的分析.
  • 基因组分析以确定同时发生的突变 (Kras, p53).

主要成果:

  • 恢复APC功能导致诱导肠道瘤的完全回归.
  • 在APC恢复后,瘤细胞恢复了正常分化和干细胞特征.
  • 无论瘤中是否存在Kras和p53突变,都可以观察到这些效应.
  • 验证了Wnt信号通路作为癌症干预的关键目标.

结论:

  • 恢复APC功能是完全肠道瘤回归的可行策略.
  • 在维持肠道平衡和预防瘤发生方面,APC功能是核心的.
  • Wnt途径代表了结直肠癌治疗的有前途的治疗标.